In silico evaluation of aminopropyl imidazole derivatives of glycyrrhetinic acid: The effect of structural modification on the spectrum of biological activity
Keywords:
Glitsirret kislota, Aminopropil imidazol hosilalari, In silico tahlil, PASS Online, Biologik faollik, Sitoprotektiv ta’sir, Membrana destruksiyasi, Strukturaviy modifikatsiya, Farmakologik xususiyatlar, Triterpen saponinlar.Abstract
Ushbu tadqiqotda glitsirret kislotasining (GLK) 3, 4, 5 va 6-aminopropil imidazol (API) bilan hosilalari in silico (PASS Online) tahlil qilindi. Natijalar shuni ko'rsatdiki, aminopropil zanjirining holati moddaning farmakologik yo'nalishini keskin o'zgartiradi. GLK + 3API hosilasi membrana destruksiyasi (antagonist) xususiyati bilan ajralib tursa, GLK + 4,5,6API hosilalari yuqori sitoprotektiv faollikni namoyon etdi. Eng yuqori Pa = 0.791 ko'rsatkichi GLK + 3API birikmasida qayd etildi.
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