PHARMACOLOGICAL EFFECTS OF VITAMIN DRUGS ON PREGNANT WOMEN

Authors

  • Rakhmonova Khosiyat Boburjon kizi Assistant intern of the Department of Pharmacology, Clinical Pharmacology and Medical Biotechnology, ASMI

Keywords:

vitamins, pregnancy, pharmacology, teratogenicity, folic acid, vitamin D, vitamin A, prenatal health.

Abstract

The physiological demands of pregnancy require a delicate balance between maternal and fetal nutrition, metabolism, and hormonal regulation. Vitamins — both water- and fat-soluble — play essential roles in supporting cellular growth, hematopoiesis, nervous system development, and immune competence during gestation. The pharmacological use of vitamin preparations in pregnant women aims to prevent nutritional deficiencies, fetal malformations, and pregnancy-related complications such as anemia, preeclampsia, and neural tube defects. However, excessive or inappropriate vitamin supplementation may lead to teratogenic or toxic effects, particularly with fat-soluble compounds. This article presents an in-depth analysis of the pharmacological mechanisms, benefits, and potential risks associated with vitamin drug use in pregnant women. It explores the kinetics of vitamin absorption, distribution, and metabolism during pregnancy and underscores the importance of evidence-based supplementation guided by clinical pharmacology principles.

References

Allen, L. H. Pregnancy and lactation: physiological adjustments, nutritional requirements and the role of dietary supplements. Clinical Nutrition, 2015.

Institute of Medicine (IOM). Dietary Reference Intakes for Calcium and Vitamin D., National Academies Press, 2011.

Bailey, L. B. & Berry, R. J. Folic acid supplementation and the prevention of neural tube defects. New England Journal of Medicine, 2015.

Hollis, B. W., & Wagner, C. L. Vitamin D supplementation during pregnancy: safety and effectiveness. American Journal of Clinical Nutrition, 2017.

Rothman, K. J., et al. Teratogenicity of high vitamin A intake during pregnancy. New England Journal of Medicine, 2015.

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Published

2025-11-01

How to Cite

Rakhmonova Khosiyat Boburjon kizi. (2025). PHARMACOLOGICAL EFFECTS OF VITAMIN DRUGS ON PREGNANT WOMEN. SAMARALI TA’LIM VA BARQAROR INNOVATSIYALAR JURNALI, 3(10), 503–507. Retrieved from https://innovativepublication.uz/index.php/jelsi/article/view/4349