INDICATIONS FOR THE TREATMENT OF GASTROINTESTINAL ULCERS WITH ANTIBACTERIAL DRUGS
Keywords:
Gastrointestinal ulcers, peptic ulcer, Helicobacter pylori, antibacterial therapy, triple therapy, antimicrobial resistance, gastroenterology, ulcer complications.Abstract
This article analyzes the clinical indications for the use of antibacterial
therapy in the management of gastrointestinal (GI) ulcers. Particular emphasis is placed on
Helicobacter pylori (H. pylori)-associated peptic ulcers, non-H. pylori-related infections,
and cases involving secondary bacterial complications. The paper outlines diagnostic
criteria, pharmacological strategies, and current international guidelines for implementing
antibacterial treatment. The importance of antibiotic stewardship and resistance prevention
is also discussed.
References
Malfertheiner, P., Megraud, F., O'Morain, C. A., et al. Management of Helicobacter
pylori infection—the Maastricht V/Florence Consensus Report. – Gut. – 2017. – Vol. 66,
№1. – P. 6–30.
Chey, W. D., Wong, B. C., and the Practice Parameters Committee of the American
College of Gastroenterology. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. – Am J Gastroenterol. – 2007. – Vol. 102,
№8. – P. 1808–1825.
Kwon, Y. H., Kim, N. Management strategies for antibiotic-resistant Helicobacter pylori
infection: 2022 update. – World J Gastroenterol. – 2022. – Vol. 28, №3. – P. 243–261.
Graham, D. Y., Shiotani, A. Which therapy for Helicobacter pylori infection? –
Gastroenterology. – 2012. – Vol. 143, №1. – P. 10–12.
Sugano, K., Tack, J., Kuipers, E. J., et al. Kyoto global consensus report on Helicobacter
pylori gastritis. – Gut. – 2015. – Vol. 64, №9. – P. 1353–1367.
