Pathogenetic aspects of cardiovascular disorders in carbon monoxide poisoning and ways of their correction
Keywords:
carbon monoxide,cardiovascular , methylene blue, CK, LDH, troponin,CD31, HHF35 aktin.Abstract
Carbon monoxide (CO) poisoning leads to cardiovascular disorders due
to reduced oxygen delivery and cellular dysfunction. CO binds to hemoglobin, forming
carboxyhemoglobin, impairing oxygen transport and causing systemic hypoxia. This
triggers oxidative stress, inflammation, and endothelial dysfunction, contributing to
arrhythmias, hypotension, and myocardial injury. The primary treatment, including
oxygen therapy and hyperbaric oxygen, helps reduce CO levels and improve oxygenation.
Emerging therapies targeting oxidative stress and inflammation are being explored to
prevent long-term cardiovascular complications. Early detection and appropriate treatment
are crucial to improving outcomes in CO poisoning.
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